Hydrochloric Acid → HCID 50940430, compound

HRID 269697Notes

Reaction equation

HRID 269697 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11](=[O:72])[CH2:12][C@@H:13]([NH:25][C:26]([C@H:28]1[NH:46][C:45](=[O:47])[C@H:44]([CH2:48][CH2:49][CH2:50][NH:51]C(OC(C)(C)C)=O)[NH:43][C:42](=[O:59])[C@@H:41]([NH:60]C(OC(C)(C)C)=O)[CH2:40][C:39]2[CH:68]=[C:35]([CH:36]=[CH:37][C:38]=2[OH:69])[C:34]2=[CH:70][C:30](=[C:31]([OH:71])[CH:32]=[CH:33]2)[CH2:29]1)=[O:27])[CH2:14][CH2:15][CH2:16][NH:17]C(OC(C)(C)C)=O)(C)(C)C.[ClH:74]>O1CCOCC1>[ClH:74].[ClH:74].[ClH:74].[ClH:74].[NH2:60][C@H:41]1[CH2:40][C:39]2[CH:68]=[C:35]([CH:36]=[CH:37][C:38]=2[OH:69])[C:34]2=[CH:70][C:30](=[C:31]([OH:71])[CH:32]=[CH:33]2)[CH2:29][C@@H:28]([C:26]([NH:25][C@H:13]([CH2:12][C:11]([NH:10][CH2:9][CH2:8][NH2:7])=[O:72])[CH2:14][CH2:15][CH2:16][NH2:17])=[O:27])[NH:46][C:45](=[O:47])[C@H:44]([CH2:48][CH2:49][CH2:50][NH2:51])[NH:43][C:42]1=[O:59]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131727174HCID 131727174, compound

Product 1

HCID 50940430HCID 50940430, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 30 mg (0.029 mmol) of tert-butyl(2-{[(3S)-6-[(tert-butoxycarbonyl)amino]-3-({[(8S,11S,14S)-14-[(tert-butoxycarbonyl)amino]-11-{3-[(tert-butoxycarbonyl)amino]propyl}-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}amino)hexanoyl]amino}ethyl)carbamate (Example 193A) in 2 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 20 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-8dfbf478afef4985920ddf03bb97a6ff
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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