HRID269699

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

反应SMILES：CC(C)(C)OC(=O)NCCC[C@@H]1NC(=O)[C@@H](NC(=O)OC(C)(C)C)Cc2cc(ccc2O)-c2ccc(O)c(c2)C[C@@H](C(=O)N[C@@H](CCN)C(=O)NCCN)NC1=O

HCID70806728

未命名化合物

PRODUCTS

产物

反应SMILES：Cl.Cl.Cl.Cl.NCCC[C@@H]1NC(=O)[C@@H](N)Cc2cc(ccc2O)-c2ccc(O)c(c2)C[C@@H](C(=O)N[C@@H](CCN)C(=O)NCCN)NC1=O

HCID50940434

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

15 mg (0.019 mmol) of tert-butyl{3-[(8S,11S,14S)-8-{[((1S)-3-amino-1-{[(2-aminoethyl)amino]carbonyl}propyl)amino]carbonyl}-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate bis(hydroacetate) (Example 207A) are added into 1 ml of a 4N solution of hydrogen chloride in dioxane and stirred at RT for 20 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

WORKUP

后处理

concentrationThe reaction solution is concentrated
customdried under high vacuum

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-42987922d3c341318f46ee70aeb96069
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07446102B2
来源说明: uspto-grants-2008_11

反应SMILES

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@@H:11]1[NH:29][C:28](=[O:30])[C@@H:27]([NH:31]C(OC(C)(C)C)=O)[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:50]([NH:52][CH2:53][CH2:54][NH2:55])=[O:51])[CH2:47][CH2:48][NH2:49])=[O:44])[NH:13][C:12]1=[O:56])(C)(C)C.[ClH:58]>O1CCOCC1>[ClH:58].[ClH:58].[ClH:58].[ClH:58].[NH2:31][C@H:27]1[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:50]([NH:52][CH2:53][CH2:54][NH2:55])=[O:51])[CH2:47][CH2:48][NH2:49])=[O:44])[NH:13][C:12](=[O:56])[C@H:11]([CH2:10][CH2:9][CH2:8][NH2:7])[NH:29][C:28]1=[O:30]