Hydrochloric Acid → HCID 50940434, compound

HRID 269699Notes

Reaction equation

HRID 269699 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@@H:11]1[NH:29][C:28](=[O:30])[C@@H:27]([NH:31]C(OC(C)(C)C)=O)[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:50]([NH:52][CH2:53][CH2:54][NH2:55])=[O:51])[CH2:47][CH2:48][NH2:49])=[O:44])[NH:13][C:12]1=[O:56])(C)(C)C.[ClH:58]>O1CCOCC1>[ClH:58].[ClH:58].[ClH:58].[ClH:58].[NH2:31][C@H:27]1[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:50]([NH:52][CH2:53][CH2:54][NH2:55])=[O:51])[CH2:47][CH2:48][NH2:49])=[O:44])[NH:13][C:12](=[O:56])[C@H:11]([CH2:10][CH2:9][CH2:8][NH2:7])[NH:29][C:28]1=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70806728HCID 70806728, compound

Product 1

HCID 50940434HCID 50940434, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

15 mg (0.019 mmol) of tert-butyl{3-[(8S,11S,14S)-8-{[((1S)-3-amino-1-{[(2-aminoethyl)amino]carbonyl}propyl)amino]carbonyl}-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate bis(hydroacetate) (Example 207A) are added into 1 ml of a 4N solution of hydrogen chloride in dioxane and stirred at RT for 20 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-42987922d3c341318f46ee70aeb96069
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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