Hydrochloric Acid → HCID 178478578, compound

Participants

Reaction Steps

5.3 mg (0.005 mmol) of tert-butyl{3-[(8S,11S,14S)-8-{[((1S)-1-{[(2-aminoethyl)amino]carbonyl}-4-{[amino(imino)methyl]amino}butyl)amino]carbonyl}-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate di(hydrotrifluoroacetate) (Example 209A) are added into 0.4 ml of a 4N solution of hydrogen chloride in dioxane and stirred at RT for 30 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

Provenance & Evidence