Hydrochloric Acid → HCID 178478578, compound

HRID 269701Notes

Reaction equation

HRID 269701 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@@H:11]1[NH:29][C:28](=[O:30])[C@@H:27]([NH:31]C(OC(C)(C)C)=O)[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:54]([NH:56][CH2:57][CH2:58][NH2:59])=[O:55])[CH2:47][CH2:48][CH2:49][NH:50][C:51]([NH2:53])=[NH:52])=[O:44])[NH:13][C:12]1=[O:60])(C)(C)C.[ClH:62]>O1CCOCC1>[ClH:62].[ClH:62].[ClH:62].[ClH:62].[ClH:62].[NH2:31][C@H:27]1[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:54]([NH:56][CH2:57][CH2:58][NH2:59])=[O:55])[CH2:47][CH2:48][CH2:49][NH:50][C:51]([NH2:53])=[NH:52])=[O:44])[NH:13][C:12](=[O:60])[C@H:11]([CH2:10][CH2:9][CH2:8][NH2:7])[NH:29][C:28]1=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453438HCID 178453438, compound

Product 1

HCID 178478578HCID 178478578, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.3 mg (0.005 mmol) of tert-butyl{3-[(8S,11S,14S)-8-{[((1S)-1-{[(2-aminoethyl)amino]carbonyl}-4-{[amino(imino)methyl]amino}butyl)amino]carbonyl}-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate di(hydrotrifluoroacetate) (Example 209A) are added into 0.4 ml of a 4N solution of hydrogen chloride in dioxane and stirred at RT for 30 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-95d8b283683242f8b010468202b532d1
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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