Hydrochloric Acid → HCID 50938586, compound

HRID 269702Notes

Reaction equation

HRID 269702 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@H:11]([NH:36][C:37]([C@H:39]1[NH:57][C:56](=[O:58])[C@H:55]([CH2:59][CH2:60][CH2:61][NH:62]C(OC(C)(C)C)=O)[NH:54][C:53](=[O:70])[C@@H:52]([NH:71]C(OC(C)(C)C)=O)[CH2:51][C:50]2[CH:79]=[C:46]([CH:47]=[CH:48][C:49]=2[OH:80])[C:45]2=[CH:81][C:41](=[C:42]([OH:82])[CH:43]=[CH:44]2)[CH2:40]1)=[O:38])[C:12]([NH:14][CH2:15][C@@H:16]([NH:28]C(OC(C)(C)C)=O)[CH2:17][CH2:18][CH2:19][NH:20]C(OC(C)(C)C)=O)=[O:13])(C)(C)C.[ClH:84]>O1CCOCC1>[ClH:84].[ClH:84].[ClH:84].[ClH:84].[NH2:71][C@H:52]1[CH2:51][C:50]2[CH:79]=[C:46]([CH:47]=[CH:48][C:49]=2[OH:80])[C:45]2=[CH:81][C:41](=[C:42]([OH:82])[CH:43]=[CH:44]2)[CH2:40][C@@H:39]([C:37]([NH:36][C@H:11]([C:12]([NH:14][CH2:15][C@@H:16]([NH2:28])[CH2:17][CH2:18][CH2:19][NH2:20])=[O:13])[CH2:10][CH2:9][CH2:8][NH2:7])=[O:38])[NH:57][C:56](=[O:58])[C@H:55]([CH2:59][CH2:60][CH2:61][NH2:62])[NH:54][C:53]1=[O:70]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89290804HCID 89290804, compound

Product 1

HCID 50938586HCID 50938586, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

40 mg (0.034 mmol) of the compound from Example 177A are dissolved at 0° C. in 1 ml of dioxane. Then 0.5 ml of a 4N hydrogen chloride solution in dioxane are added and the mixture is stirred at RT for 2 h. The mixture is evaporated to dryness in vacuo and the residue is dried to constant weight under high vacuum.

Workup

  1. customThe mixture is evaporated to dryness in vacuo
  2. customthe residue is dried to constant weight under high vacuum

Sources & evidence

ORD record
ord-916a574f0e734675bffd462c160aa9c2
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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