Hydrochloric Acid → HCID 50938584, compound

HRID 269703Notes

Reaction equation

HRID 269703 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:20][NH:21][C:22](=[O:71])[CH2:23][NH:24][C:25]([C@H:27]1[NH:45][C:44](=[O:46])[C@H:43]([CH2:47][CH2:48][CH2:49][NH:50]C(OC(C)(C)C)=O)[NH:42][C:41](=[O:58])[C@@H:40]([NH:59]C(OC(C)(C)C)=O)[CH2:39][C:38]2[CH:67]=[C:34]([CH:35]=[CH:36][C:37]=2[OH:68])[C:33]2=[CH:69][C:29](=[C:30]([OH:70])[CH:31]=[CH:32]2)[CH2:28]1)=[O:26])[CH2:9][CH2:10][CH2:11][NH:12]C(OC(C)(C)C)=O)(C)(C)C.[ClH:73]>O1CCOCC1>[ClH:73].[ClH:73].[ClH:73].[ClH:73].[NH2:59][C@H:40]1[CH2:39][C:38]2[CH:67]=[C:34]([CH:35]=[CH:36][C:37]=2[OH:68])[C:33]2=[CH:69][C:29](=[C:30]([OH:70])[CH:31]=[CH:32]2)[CH2:28][C@@H:27]([C:25]([NH:24][CH2:23][C:22]([NH:21][CH2:20][C@@H:8]([NH2:7])[CH2:9][CH2:10][CH2:11][NH2:12])=[O:71])=[O:26])[NH:45][C:44](=[O:46])[C@H:43]([CH2:47][CH2:48][CH2:49][NH2:50])[NH:42][C:41]1=[O:58]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 88986935HCID 88986935, compound

Product 1

HCID 50938584HCID 50938584, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

11.5 mg (0.011 mmol) of the compound from Example 178A are dissolved at 0° C. in 1 ml of dioxane. Then, 0.2 ml of a 4N hydrogen chloride solution in dioxane are added and the mixture is stirred at RT for 2 h. The mixture is evaporated to dryness in vacuo, and the residue is dried to constant weight under high vacuum.

Workup

  1. customThe mixture is evaporated to dryness in vacuo
  2. customthe residue is dried to constant weight under high vacuum

Sources & evidence

ORD record
ord-3602db2195fa4331b220a4ec6644bf67
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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