Hydrochloric Acid → HCID 50938802, compound

HRID 269704Notes

Reaction equation

HRID 269704 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:20][NH:21][C:22](=[O:73])[C@@H:23]([NH:26][C:27]([C@H:29]1[NH:47][C:46](=[O:48])[C@H:45]([CH2:49][CH2:50][CH2:51][NH:52]C(OC(C)(C)C)=O)[NH:44][C:43](=[O:60])[C@@H:42]([NH:61]C(OC(C)(C)C)=O)[CH2:41][C:40]2[CH:69]=[C:36]([CH:37]=[CH:38][C:39]=2[OH:70])[C:35]2=[CH:71][C:31](=[C:32]([OH:72])[CH:33]=[CH:34]2)[CH2:30]1)=[O:28])[CH2:24][OH:25])[CH2:9][CH2:10][CH2:11][NH:12]C(OC(C)(C)C)=O)(C)(C)C.[ClH:75]>O1CCOCC1>[ClH:75].[ClH:75].[ClH:75].[ClH:75].[NH2:61][C@H:42]1[CH2:41][C:40]2[CH:69]=[C:36]([CH:37]=[CH:38][C:39]=2[OH:70])[C:35]2=[CH:71][C:31](=[C:32]([OH:72])[CH:33]=[CH:34]2)[CH2:30][C@@H:29]([C:27]([NH:26][C@@H:23]([CH2:24][OH:25])[C:22]([NH:21][CH2:20][C@@H:8]([NH2:7])[CH2:9][CH2:10][CH2:11][NH2:12])=[O:73])=[O:28])[NH:47][C:46](=[O:48])[C@H:45]([CH2:49][CH2:50][CH2:51][NH2:52])[NH:44][C:43]1=[O:60]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89290806HCID 89290806, compound

Product 1

HCID 50938802HCID 50938802, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

18.4 mg (0.018 mmol) of the compound from Example 179A are dissolved at 0° C. in 1 ml of dioxane. Then 0.26 ml of a 4N hydrogen chloride solution in dioxane are added and the mixture is stirred at RT for 4 h. The mixture is evaporated to dryness in vacuo, and the residue is dried to constant weight under high vacuum.

Workup

  1. customThe mixture is evaporated to dryness in vacuo
  2. customthe residue is dried to constant weight under high vacuum

Sources & evidence

ORD record
ord-4a2b960f53a2482c91ce2812b716dff2
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

Loading…