Hydrazine hydrate (1:1) → HCID 11545497, compound

HRID 269788Notes

Reaction equation

HRID 269788 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](S(C)(=O)=O)[N:5]=[C:4]([NH:12][C@H:13]([C:15]([F:18])([F:17])[F:16])[CH3:14])[C:3]=1[C:19]1[C:24]([F:25])=[CH:23][C:22]([F:26])=[CH:21][C:20]=1[F:27].O.[NH2:29][NH2:30]>>[Cl:1][C:2]1[N:7]=[C:6]([NH:29][NH2:30])[N:5]=[C:4]([NH:12][C@H:13]([C:15]([F:18])([F:17])[F:16])[CH3:14])[C:3]=1[C:19]1[C:24]([F:25])=[CH:23][C:22]([F:26])=[CH:21][C:20]=1[F:27]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11327963HCID 11327963, compound

Product 1

HCID 11545497HCID 11545497, compound

Procedure

An ethanolic solution of 0.5 g (1.15 mmol) of sulfone 1 and 0.13 g (2.54 mmol) of hydrazine hydrate was stirred at 20-25° C. for 2 hours. The solvent was distilled off and the residue was digested with diisopropyl ether, and the residue was then filtered off and washed with diisopropyl ether/hexane 1:1.

Workup

  1. distillationThe solvent was distilled off
  2. filtrationthe residue was then filtered off
  3. washwashed with diisopropyl ether/hexane 1:1

Sources & evidence

ORD record
ord-070d81ffecc343e9af0100bdd1eb74c4
Source dataset
uspto-grants-2008_11
Patent number
US07449471B2

Reaction notes

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