2-Fluoro-4-nitrotoluene → 2-(4-Amino-2-fluorophenyl)ethanol

HRID 269804ノート

反応式

HRID 269804 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH3:11].[CH3:12][O-:13].[Na+]>CS(C)=O>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][OH:13])[NH2:8]

参加物

4

反応物 2

HCID 740252-Fluoro-4-nitrotolueneHCID 10942334Sodium Methoxide

生成物 1

HCID 450906002-(4-Amino-2-fluorophenyl)ethanol

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

2-Fluoro-4-nitrotoluene and p-formaldehyde were allowed to undergo the reaction in DMSO in the presence of sodium methoxide, and then the resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 3-fluoro-4-(2-hydroxyethyl)aniline. F: 156.

出典と根拠

ORDレコード
ord-a0076cd7d98346488810ae7fab1d0183
出典データセット
uspto-grants-2008_11
特許番号
US07449456B2

反応ノート

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