2-(Methylamino)ethanol → 3-(N-2-hydroxyethyl-N-methylamino)benzonitrile

HRID 269824Notes

Reaction equation

HRID 269824 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].[CH3:10][NH:11][CH2:12][CH2:13][OH:14]>>[OH:14][CH2:13][CH2:12][N:11]([C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6])[CH3:10]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 678803-Fluorobenzonitrile

Product 1

HCID 586560573-(N-2-hydroxyethyl-N-methylamino)benzonitrile

Procedure

By treating 3-fluorobenzonitrile with N-methylethanolamine under heating, 3-(N-2-hydroxyethyl-N-methylamino)benzonitrile was obtained (F: 177). This benzonitrile was treated in the same manner as in Reference Example 2 to obtain 3-(N-2-hydroxyethyl-N-methylamino)benzylamine. F: 181.

Workup

  1. temperatureunder heating

Sources & evidence

ORD record
ord-9167b37dde5e4e1e836713f66af748df
Source dataset
uspto-grants-2008_11
Patent number
US07449456B2

Reaction notes

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