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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269824Generated: October 26, 2026

2-(Methylamino)ethanol → 3-(N-2-hydroxyethyl-N-methylamino)benzonitrile

https://huagongshe.com/reaction/269824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Methylamino)ethanolHCID 8016—
Reactant3-FluorobenzonitrileHCID 67880—
Product3-(N-2-hydroxyethyl-N-methylamino)benzonitrileHCID 58656057—

Reaction Steps

By treating 3-fluorobenzonitrile with N-methylethanolamine under heating, 3-(N-2-hydroxyethyl-N-methylamino)benzonitrile was obtained (F: 177). This benzonitrile was treated in the same manner as in Reference Example 2 to obtain 3-(N-2-hydroxyethyl-N-methylamino)benzylamine. F: 181.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07449456B2
Source datasetuspto-grants-2008_11
ORD IDord-9167b37dde5e4e1e836713f66af748df
Source noteuspto-grants-2008_11