1-(4-Methoxy-2-methylphenyl)-4-phenethylpiperazine → HCID 23111433, compound

HRID 269872Notes

Reaction equation

HRID 269872 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.C[O:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:37][CH2:36][N:35]([CH2:38][CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH2:34][CH2:33]2)=[C:28]([CH3:46])[CH:27]=1>>[CH3:46][C:28]1[CH:27]=[C:26]([OH:25])[CH:31]=[CH:30][C:29]=1[N:32]1[CH2:33][CH2:34][N:35]([CH2:38][CH2:39][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH2:36][CH2:37]1

Participants

3

Reactant 2

HCID 231114681-(4-Methoxy-2-methylphenyl)-4-phenethylpiperazineHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 23111433HCID 23111433, compoundYield 85.3%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(4-methoxy-2-methylphenyl)-4-phenethylpiperazine (512 mg), and the resulting crude product was purified on TLC (developer, chloroform: methanol=15:1) to provide 3-methyl-4-(4-phenethyl-piperazin-1-yl)phenol (417 mg).

Workup

  1. customthe resulting crude product was purified on TLC (developer, chloroform: methanol=15:1)

Sources & evidence

ORD record
ord-dd4ec3476b8746cfaacddae4450b0b2f
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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