HCID 23111457, compound → HCID 23111417, compound

HRID 269873Notes

Reaction equation

HRID 269873 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.C[O:25][C:26]1[CH:27]=[CH:28][C:29]([N:34]2[CH2:39][CH2:38][CH:37]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH2:36][CH2:35]2)=[C:30]([CH:33]=1)[C:31]#[N:32]>>[OH:25][C:26]1[CH:27]=[CH:28][C:29]([N:34]2[CH2:39][CH2:38][CH:37]([C:40]3[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=3)[CH2:36][CH2:35]2)=[C:30]([CH:33]=1)[C:31]#[N:32]

Participants

3

Reactant 2

HCID 23111457HCID 23111457, compoundHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 23111417HCID 23111417, compoundYield 44.6%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 5-methoxy-2-(4-phenylpiperidino)benzonitrile (99 mg), and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1) to provide 5-hydroxy-2-(4-phenylpiperidino)benzonitrile (42 mg).

Workup

  1. customthe resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1)

Sources & evidence

ORD record
ord-ae4e50c17d334b54a60db97c06bf3c3c
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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