HCID 23111430, compound → HCID 23111397, compound

HRID 269874Notes

Reaction equation

HRID 269874 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[CH2:24]([CH:31]1[CH2:36][CH2:35][N:34]([C:37]2[CH:44]=[CH:43][C:42]([O:45]C)=[CH:41][C:38]=2[C:39]#[N:40])[CH2:33][CH2:32]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([CH:31]1[CH2:32][CH2:33][N:34]([C:37]2[CH:44]=[CH:43][C:42]([OH:45])=[CH:41][C:38]=2[C:39]#[N:40])[CH2:35][CH2:36]1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 23111430HCID 23111430, compoundHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 23111397HCID 23111397, compoundYield 42.3%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 2-(4-benzylpiperidino)-5-methoxybenzonitrile (99 mg), and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1) to provide 2-(4-benzylpiperidino)-5-hydroxy-benzonitrile (40 mg).

Workup

  1. customthe resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1)

Sources & evidence

ORD record
ord-9d0280122f1e4213bf78edaf4549acb4
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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