HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine → 2-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-5-hydroxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine | HCID 23111510 | — |
| Reactant | 2-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-5-methoxybenzonitrile | HCID 23111513 | — |
| Product | 2-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-5-hydroxybenzonitrile | HCID 23111447 | 62.1% |
Reaction Steps
Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 2-[4-(3-cyclohexylpropyl)piperazin-1-yl]-5-methoxybenzonitrile (430 mg), and the resulting crude product was purified on TLC (developer, chloroform: methanol=10:1) to provide 2-[4-(3-cyclohexylpropyl)piperazin-1-yl]-5-hydroxybenzonitrile (256 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-fd8057679ebb47129fadc986d61d573f |
| Source note | uspto-grants-2008_11 |