反应详情

1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)-piperazine (1.21 g) was suspended in acetic acid (6.0 mL), and to the suspension conc. hydrochloric acid (2.83 mL) was added, followed by 2 hours' heating under reflux. Allowing the system to cool off, the solvent was distilled off under reduced pressure, and the remaining crystals were washed with acetone and dried under reduced pressure at 60° C., to provide 2-chloro-4-[4-(3-cyclohexylpropyl)piperazin-1-yl]-phenol hydrochloride (760 mg).

1. temperature' heating
2. temperatureunder reflux
3. temperatureto cool off
4. distillationthe solvent was distilled off under reduced pressure
5. washthe remaining crystals were washed with acetone
6. customdried under reduced pressure at 60° C.