反应详情

To 1-(4-benzyloxy-3-chlorophenyl)piperazine (4.739 g), acetic acid (20 mL) and conc. hydrochloric acid (10 mL) were added, followed by 1.5 hours' heating under reflux. The reaction liquid was let stand to cool off, and from which the solvent was distilled off by heating under reduced pressure. The crude product was suspended in tetrahydrofuran, recovered by filtration, washed with tetrahydrofuran and dried by heating under reduced pressure to provide 2-chloro-4-(piperazin-1-yl)phenol hydrochloride (4.050 g).

1. temperature' heating
2. temperatureunder reflux
3. customThe reaction liquid
4. temperatureto cool off
5. distillationfrom which the solvent was distilled off
6. temperatureby heating under reduced pressure
7. filtrationrecovered by filtration
8. washwashed with tetrahydrofuran
9. customdried
10. temperatureby heating under reduced pressure