HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 3-Chloro-4-(4-phenethylpiperazin-1-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine | HCID 23111408 | — |
| Reactant | 1-(4-Benzyloxy-2-chlorophenyl)-4-phenethylpiperazine | HCID 23111462 | — |
| Product | 3-Chloro-4-(4-phenethylpiperazin-1-yl)phenol | HCID 23111423 | 57.3% |
Reaction Steps
Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-2-chlorophenyl)-4-phenethylpiperazine (65 mg). Thus obtained crude product was purified on TLC (developer, chloroform: methanol=17:1) to provide 3-chloro-4-(4-phenethylpiperazin-1-yl)phenol (29 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-77d3e002ee714f3e8073cfe440fda64d |
| Source note | uspto-grants-2008_11 |