HCID 23111502, compound → HCID 86607272, compound

HRID 269891Notes

Reaction equation

HRID 269891 reaction equation
COC1C=CC(N2CCN([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)CC2)=CC=1C.C1(CC[N:32]2[CH2:37][CH2:36][N:35]([C:38]3[CH:43]=[CH:42][C:41]([O:44]C)=[C:40]([F:46])[CH:39]=3)[CH2:34][CH2:33]2)CCCCC1>>[CH:17]1([CH2:16][CH2:15][CH:34]2[CH2:33][NH:32][CH2:37][CH2:36][N:35]2[C:38]2[CH:43]=[CH:42][C:41]([OH:44])=[C:40]([F:46])[CH:39]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 23111502HCID 23111502, compoundHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 86607272HCID 86607272, compound

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2-cyclohexylethyl)-4-(3-fluoro-4-methoxyphenyl)piperazine (218 mg) and the resulting crude product was purified on TLC (developer, chloroform: methanol=18:1) to provide 4-[4-(2-cyclohexylethyl-piperazin-1-yl]-2-fluorophenol (77 mg).

Workup

  1. customthe resulting crude product was purified on TLC (developer, chloroform: methanol=18:1)

Sources & evidence

ORD record
ord-ada700e9bb9b494fbefc1226b239aefd
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

Loading…