HCID 23111491, compound → HCID 23111412, compound

HRID 269892Notes

Reaction equation

HRID 269892 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[F:24][C:25]1[CH:26]=[C:27]([N:33]2[CH2:38][CH2:37][N:36]([CH2:39][CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH2:35][CH2:34]2)[CH:28]=[CH:29][C:30]=1[O:31]C>>[F:24][C:25]1[CH:26]=[C:27]([N:33]2[CH2:34][CH2:35][N:36]([CH2:39][CH2:40][C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH2:37][CH2:38]2)[CH:28]=[CH:29][C:30]=1[OH:31]

Participants

3

Reactant 2

HCID 23111491HCID 23111491, compoundHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 23111412HCID 23111412, compoundYield 38%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(3-fluoro-4-methoxyphenyl)-4-phenethylpiperazine (482 mg), and the resulting crude product was purified on TLC (developer, chloroform: methanol=17:1) to provide 2-fluoro-4-(4-phenethylpiperazin-1-yl)phenol (175 mg).

Workup

  1. customthe resulting crude product was purified on TLC (developer, chloroform: methanol=17:1)

Sources & evidence

ORD record
ord-b7ee3e8edcef4ad3a1c4ff6670254ad3
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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