HCID 23111451, compound → HCID 23111436, compound

HRID 269908Notes

Reaction equation

HRID 269908 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[F:24][C:25]1[CH:30]=[C:29]([O:31]C)[CH:28]=[CH:27][C:26]=1[N:33]1[CH2:38][CH2:37][N:36]([CH2:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[CH2:35][CH2:34]1>>[F:24][C:25]1[CH:30]=[C:29]([OH:31])[CH:28]=[CH:27][C:26]=1[N:33]1[CH2:38][CH2:37][N:36]([CH2:39][CH2:40][C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 23111451HCID 23111451, compoundHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 23111436HCID 23111436, compoundYield 50.8%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2-fluoro-4-methoxyphenyl)-4-phenethylpiperazine (367 mg), and the resulting crude product was purified on TLC (developer, chloroform: methanol=17:1) to provide 3-fluoro-4-(4-phenethyl-piperazin-1-yl)phenol (178 mg).

Workup

  1. customthe resulting crude product was purified on TLC (developer, chloroform: methanol=17:1)

Sources & evidence

ORD record
ord-a8646fb48410429faeb5da8ed5596706
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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