HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine → 2,5-Difluoro-4-[4-(3-phenylpropyl)piperidino]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine | HCID 23111506 | — |
| Reactant | 1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine | HCID 23111510 | — |
| Product | 2,5-Difluoro-4-[4-(3-phenylpropyl)piperidino]phenol | HCID 23111394 | 32.2% |
Reaction Steps
Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine (230 mg). The resulting crude product was purified on TLC (developer, hexane: ethyl acetate=3:1) to provide 2,5-difluoro-4-[4-(3-phenylpropyl)piperidino]phenol (71 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-5afcd5f2d0294d22af442930a2be759c |
| Source note | uspto-grants-2008_11 |