反应详情

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 1-[1-(2,5-difluoro-4-methoxyphenyl)-4-piperidylcarbonyl]piperidine (406 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=12:1) to provide 1-[1-(2,5-difluoro-4-hydroxyphenyl)-4-piperidylcarbonyl]piperidine (178 mg).

1. customThe resulting crude product was purified on TLC (developer, chloroform: methanol=12:1)