HCID 23111498, compound → HCID 23111472, compound

HRID 269922Notes

Reaction equation

HRID 269922 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[CH2:24]([N:34]1[CH2:39][CH2:38][N:37]([C:40]2[CH:45]=[C:44]([F:46])[C:43]([O:47]C)=[CH:42][C:41]=2[F:49])[CH2:36][CH2:35]1)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]>>[CH2:24]([N:34]1[CH2:35][CH2:36][N:37]([C:40]2[C:41]([F:49])=[CH:42][C:43]([OH:47])=[C:44]([F:46])[CH:45]=2)[CH2:38][CH2:39]1)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]

Participants

3

Reactant 2

HCID 23111498HCID 23111498, compoundHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 23111472HCID 23111472, compoundYield 39.6%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-decyl-4-(2,5-difluoro-4-methoxyphenyl)piperazine (176 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=19:1) to provide 4-(4-decylpiperazin-1-yl)-2,5-difluorophenol (67 mg).

Workup

  1. customThe resulting crude product was purified on TLC (developer, chloroform: methanol=19:1)

Sources & evidence

ORD record
ord-c09401c6674e49d9bdbb3ac59c838c94
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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