HCID 23111449, compound → HCID 23111511, compound

HRID 269930Notes

Reaction equation

HRID 269930 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[CH:24]1([CH2:30][CH2:31][CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][N:37]([C:40]3[CH:45]=[C:44]([F:46])[C:43]([O:47]C)=[CH:42][C:41]=3[F:49])[CH2:36][CH2:35]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([CH2:30][CH2:31][CH2:32][CH2:33][N:34]2[CH2:35][CH2:36][N:37]([C:40]3[C:41]([F:49])=[CH:42][C:43]([OH:47])=[C:44]([F:46])[CH:45]=3)[CH2:38][CH2:39]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 23111449HCID 23111449, compoundHCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine

Product 1

HCID 23111511HCID 23111511, compoundYield 27.6%

Procedure

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(4-cyclohexylbutyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (482 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=16:1) to provide 4-[4-(4-cyclohexylbutyl)piperazin-1-yl]-2,5-difluorophenol (128 mg).

Workup

  1. customThe resulting crude product was purified on TLC (developer, chloroform: methanol=16:1)

Sources & evidence

ORD record
ord-0da9c2c84e8347d3a524f38364565321
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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