Isovaleryl chloride → HCID 23111486, compound

HRID 269935Notes

Reaction equation

HRID 269935 reaction equation
Cl.Cl.C[O:4][C:5]1[CH:10]=[CH:9][C:8](N2CCNCC2)=[CH:7][CH:6]=1.[C:17](Cl)(=O)[CH2:18][CH:19](C)[CH3:20].[F:24][C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([F:33])=[CH:27][C:26]=1[N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>C(Cl)(=O)CCCCCCCCC>[C:5]([N:37]1[CH2:38][CH2:39][N:34]([C:26]2[CH:27]=[C:28]([F:33])[C:29]([O:31][CH3:32])=[CH:30][C:25]=2[F:24])[CH2:35][CH2:36]1)(=[O:4])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:17][CH2:18][CH2:19][CH3:20]

Participants

5

Reactant 3

HCID 66054Isovaleryl chlorideHCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochlorideHCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

Product 1

HCID 23111486HCID 23111486, compound

Reagents, catalysts & solvents 1

HCID 66982Decanoyl chlorideSolvent

Procedure

Production Example 3 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (228 mg) and decanoyl chloride (205 μL), respectively, to provide crude 1-decanoyl-4-(2,5-difluoro-4-methoxyphenyl)piperazine (371 mg).

Sources & evidence

ORD record
ord-60415504aa094f4ab37dc8a9fd1a0d25
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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