Benzenepropanoyl chloride → HCID 23111458, compound

HRID 269939Notes

Reaction equation

HRID 269939 reaction equation
Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1.C(Cl)(=O)CC(C)C.[F:24][C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([F:33])=[CH:27][C:26]=1[N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.[C:40]1([CH2:46][CH2:47][C:48](Cl)=[O:49])[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>>[F:24][C:25]1[CH:30]=[C:29]([O:31][CH3:32])[C:28]([F:33])=[CH:27][C:26]=1[N:34]1[CH2:39][CH2:38][N:37]([C:48](=[O:49])[CH2:47][CH2:46][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:36][CH2:35]1

Participants

5

Reactant 4

HCID 64801Benzenepropanoyl chlorideHCID 66054Isovaleryl chlorideHCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochlorideHCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

Product 1

HCID 23111458HCID 23111458, compound

Procedure

Production Example 3 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (228 mg) and 3-phenylpropionyl chloride (178 μL), respectively, to provide crude 4-(2,5-difluoro-4-methoxyphenyl)-1-(3-phenylpropanoyl)piperazine (348 mg).

Sources & evidence

ORD record
ord-c2ecd94126c44f9fbea11a4e4ead2f25
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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