HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)-4-phenethylpiperazine → 4-(2,5-Difluoro-4-hydroxyphenyl)-1-(octylsulfonyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)-4-phenethylpiperazine | HCID 15527076 | — |
| Reactant | 4-(2,5-Difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine | HCID 23111477 | — |
| Product | 4-(2,5-Difluoro-4-hydroxyphenyl)-1-(octylsulfonyl)piperazine | HCID 23111452 | 87.4% |
Reaction Steps
Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 4-(2,5-difluoro-4-methoxyphenyl)-1-(octylsulfonyl)piperazine (300 mg). The resulting crude product was purified on TLC (developer, hexane: ethyl acetate=11:5) to provide 4-(2,5-difluoro-4-hydroxyphenyl)-1-(octylsulfonyl)piperazine (253 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-6853523ae60544a68a174e3b0e35f827 |
| Source note | uspto-grants-2008_11 |