1-(4-Methoxyphenyl)-4-phenethylpiperazine → HCID 23111481, compound

HRID 269945Notes

Reaction equation

HRID 269945 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.[F:23][C:24]1[CH:29]=[C:28]([O:30]C)[C:27]([F:32])=[CH:26][C:25]=1[N:33]1[CH2:38][CH2:37][N:36]([S:39]([C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)(=[O:41])=[O:40])[CH2:35][CH2:34]1>>[F:23][C:24]1[CH:29]=[C:28]([OH:30])[C:27]([F:32])=[CH:26][C:25]=1[N:33]1[CH2:34][CH2:35][N:36]([S:39]([C:42]2[CH:43]=[CH:44][C:45]([F:48])=[CH:46][CH:47]=2)(=[O:41])=[O:40])[CH2:37][CH2:38]1

Participants

3

Reactant 2

HCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazineHCID 231114734-(2,5-Difluoro-4-methoxyphenyl)-1-(4-fluorophenylsulfonyl)-piperazine

Product 1

HCID 23111481HCID 23111481, compoundYield 73%

Procedure

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 4-(2,5-difluoro-4-methoxyphenyl)-1-(4-fluorophenylsulfonyl)-piperazine (300 mg). The resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1) to provide 4-(2,5-difluoro-4-hydroxyphenyl)-1-(4-fluorophenylsulfonyl)-piperazine (211 mg).

Workup

  1. customThe resulting crude product was purified on TLC (developer, hexane: ethyl acetate=2:1)

Sources & evidence

ORD record
ord-f921ac9dd4c246fa856463f4a768ccea
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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