1-(4-Methoxyphenyl)-4-phenethylpiperazine → HCID 23111495, compound

HRID 269947Notes

Reaction equation

HRID 269947 reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([S:30]([N:33]2[CH2:38][CH2:37][N:36]([C:39]3[CH:44]=[C:43]([F:45])[C:42](OC)=[CH:41][C:40]=3[F:48])[CH2:35][CH2:34]2)(=[O:32])=[O:31])=[CH:26][CH:25]=1>>[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([S:30]([N:33]2[CH2:34][CH2:35][N:36]([C:39]3[CH:44]=[C:43]([F:45])[CH:42]=[CH:41][C:40]=3[F:48])[CH2:37][CH2:38]2)(=[O:31])=[O:32])=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 155270761-(4-Methoxyphenyl)-4-phenethylpiperazineHCID 23111398HCID 23111398, compound

Product 1

HCID 23111495HCID 23111495, compoundYield 88.1%

Procedure

Production Example 2 was repeated except that 1-(4-methoxyphenyl)-4-phenethylpiperazine was replaced with 1-(4-chlorobenzenesulfonyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (395 mg). The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=2:1) to provide 1-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)-piperazine (322 mg).

Workup

  1. customThe resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=2:1)

Sources & evidence

ORD record
ord-307e24b86e874da688423a30204e0704
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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