反应详情

7-Phenyl-isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide carbamic acid t-butyl ester (1.44 g, 3.37 mmol) is dissolved in CH3OH (20 mL) and CH2Cl2 (20 mL) and HCl (37%, 5.0 mL) is added. After the mixture is stirred overnight, the mixture is concentrated and dried under high vacuum to give 1.34 g (100% yield) 7-phenyl-isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide hydrochloride. Load the product onto ion exchange resin and elute with 1N NH3 in methanol and concentrate to dryness to give the free base.

1. concentrationthe mixture is concentrated
2. customdried under high vacuum