反应详情

A suspension of methyl 2-hydroxy-4-methoxybenzoate (5.1 g, 28.0 mmol) in cyclopropyl amine 24 mL) was stirred at room temperature for 5 days. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether) to give the subtitled compound (1.8 g).

1. customThe volatiles were removed in vacuo
2. customthe residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether)