Trifluoroacetic acid water → HCID 68957620, compound

HRID 270069Notes

Reaction equation

HRID 270069 reaction equation
[C:1]([O:9][C:10]1[CH:19]=[CH:18][C:13]2[N:14]=[C:15]([CH3:17])[O:16][C:12]=2[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=[O:23].O>C([O-])(O)=O.[Na+]>[C:1]([O:9][C:10]1[CH:19]=[CH:18][C:13]([NH:14][C:15](=[O:23])[CH3:17])=[C:12]([OH:16])[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 22392675Trifluoroacetic acid waterHCID 689598582-Methyl-6-benzoyloxybenzoxazole

Product 1

HCID 68957620HCID 68957620, compound

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

To a solution of 2-methyl-1,3-benzoxazol-6-yl benzoate (5.05 g, 20 mmol) in THE (100 mL) a mixture trifluoroacetic acid/water (4 ml/10 mL) was added. The reaction mixture was stirred at room temperature for 16 h, then saurated aqueous NaHCO3 (150 mL) was added. The mixture was extracted with ethyl acetate (150 mL), dried over Na2SO4, filtered and concentrated in vacuo to give the subtitled compound.

Workup

  1. additionwas added
  2. extractionThe mixture was extracted with ethyl acetate (150 mL)
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ba9e49b9af9e45a3a88a7ea6a9ac49b6
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Reaction notes

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