Cyclopropylamine → HCID 68960505, compound

HRID 270079Notes

Reaction equation

HRID 270079 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([O:12][C:13]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:9]=[CH:8][C:3]=1[C:4](OC)=[O:5].[CH:32]1([NH2:35])[CH2:34][CH2:33]1>>[CH:32]1([NH:35][C:4](=[O:5])[C:3]2[CH:8]=[CH:9][C:10]([O:12][C:13]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:11][C:2]=2[OH:1])[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 14999687HCID 14999687, compound

Product 1

HCID 68960505HCID 68960505, compound

Procedure

Methyl 2-hydroxy-4-(trityloxy)benzoate (340 mg, 0.83 mmol) was dissolved in cyclopropylamine (3 mL) and left at room temperature for a week. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-20% ethyl acetate in petroleum ether) to give the subtitled compound (210 mg).

Workup

  1. waitleft at room temperature for a week
  2. customThe volatiles were removed in vacuo
  3. customthe residue was purified by silica gel flash chromatography (0-20% ethyl acetate in petroleum ether)

Sources & evidence

ORD record
ord-a0946a8150fa4d058ac1b164d173ed30
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Reaction notes

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