Trifluoroacetic acid → 3-(Trifluoromethyl)pyrrolidine (trifluoroacetate)

HRID 270111Notes

Reaction equation

HRID 270111 reaction equation
[F:1][C:2]([F:16])([F:15])[CH:3]1[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[C:17]([C:21]([OH:23])=[O:22])([F:20])([F:19])[F:18]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:21]([OH:23])=[O:22].[F:1][C:2]([F:16])([F:15])[CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 49760526Tert-butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate

Product 1

HCID 859154113-(Trifluoromethyl)pyrrolidine (trifluoroacetate)

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 3-(trifluoromethyl)pyrrolidine-1-carboxylate (100 mg, 0.42 mmol) was treated with 20% CF3CO2H in CH2Cl2 at room temperature overnight. The volatiles were removed in vacuo to give the subtitled compound (106 mg).

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-7f428b61f37541c99339f78fcbc55949
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Reaction notes

Loading…