反应详情

To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%).

1. temperatureThe reaction mixture was heated
2. temperaturewith reflux for 3 days
3. customThe inorganic material was removed by filtration
4. distillationThe solvent was distilled in vacuo
5. customthe residue was recrystallized from methanol