反应详情

温度

65 °C

A solution of methyl 3-hydroxy-4-nitrobenzoate (0.78 g, 3.96 mmol) in THF (40 ml) with Pd on charcoal (10%, 0.15 g) was stirred in the atmosphere of hydrogen at atmospheric pressure overnight. The mixture was filtered through celite. The solvent was removed in vacuo. The residue was taken into water (20 ml), and acetic anhydride (0.5 ml, 5.29 mmol) was added. The mixture was vigorously stirred at 65° C. for 30 min. After cooling to room temperature, the precipitate was collected by filtration, washed with water, and dried. White powder (0.64 g, 77%).

1. filtrationThe mixture was filtered through celite
2. customThe solvent was removed in vacuo
3. additionwas added
4. temperatureAfter cooling to room temperature
5. filtrationthe precipitate was collected by filtration
6. washwashed with water
7. customdried