反应详情

A mixture of 1-(chloromethyl)-4-methoxybenzene (1.53 g, 9.8 mmol), methyl 5-chloro-2,4-dihydroxybenzoate (1.98 g, 9.8 mmol) and potassiumcarbonate (1.35 g, 9.8 mmol) in acetone (15 mL) was stirred at reflux overnight. The mixture was filtered, solvent was removed in vacuo, the residue was dissolved in ethyl acetate and was washed with brine two times. The organic layer was dried over sodium sulphate, solvent was removed in vacuo and the residue was purified by recrystillaziation from methanol. (1.46 g, 46%) of the title compound was obtained.

1. temperatureat reflux overnight
2. filtrationThe mixture was filtered
3. customsolvent was removed in vacuo
4. dissolutionthe residue was dissolved in ethyl acetate
5. washwas washed with brine two times
6. dry with materialThe organic layer was dried over sodium sulphate, solvent
7. customwas removed in vacuo
8. customthe residue was purified by recrystillaziation from methanol