反应详情

A solution of N-(5-chloro-2-hydroxyphenyl)urea (0.9 g, 4.9 mmol) and (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (1.0 g, 3.8 mmol) in dimethylformamide were stirred under nitrogen. Cesium carbonate (1.9 g, 5.7 mmol) was added to the mixture and the reaction was stirred under nitrogen at room temperature over night. The mixture was partitioned between water and dichloromethane, and the organic phase was washed with water. After drying, filtration and evaporation of the solvent 0.48 g, (52%) of subtitle compound was obtained.

1. customThe mixture was partitioned between water and dichloromethane
2. washthe organic phase was washed with water
3. customAfter drying
4. filtrationfiltration and evaporation of the solvent 0.48 g, (52%) of subtitle compound
5. customwas obtained