反应详情

To a 250ml round-bottom flask equipped with a magnetic stir-bar and N2inlet was added 4-(Chloromethyl)-2-methylphenyl methyl ether (2.59g, 15.18mmoles, 1eq), dry toluene (50ml, 0.3M) and triphenylphosphine (3.98g, 15.18mmoles, 1eq). The reaction mixture was refluxed overnight. After cooling to room temperature the solvent was removed in vacuo, the residue washed with hexanes and the solid/liquid mixture was filtered to yield 4.48g (71%) of solid product.

1. customTo a 250ml round-bottom flask equipped with a magnetic stir-bar
2. temperatureThe reaction mixture was refluxed overnight
3. customwas removed in vacuo
4. washthe residue washed with hexanes
5. filtrationthe solid/liquid mixture was filtered