Diethyl Oxalate → Diethyl 2-oxo-3-(3-chlorophenyl)succinate

HRID 270208Notes

Reaction equation

[C:1]([O:8][CH2:9][CH3:10])(=[O:7])[C:2]([O:4]CC)=O.[CH2:11]([O:13][C:14](=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=1)[CH3:12]>>[O:4]=[C:2]([CH:15]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=1)[C:14]([O:13][CH2:11][CH3:12])=[O:23])[C:1]([O:8][CH2:9][CH3:10])=[O:7]

Participants

Reactant 2

HCID 7268Diethyl Oxalate

HCID 8063366Ethyl 2-(3-chlorophenyl)acetate

Product 1

HCID 21964382Diethyl 2-oxo-3-(3-chlorophenyl)succinate

Procedure

The title compound is prepared according to the method of Klioze and Ehrgott (U.S. Pat. No. 4,216,218) from diethyl oxalate and ethyl(3-chlorophenyl)acetate.

Sources & evidence

ORD record: ord-7ff6871b034e44d68f5785fc355b5d9b
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07449490B2

Reaction notes

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