1,3-Dibromopropane → 6-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene

HRID 270392Notes

Reaction equation

HRID 270392 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[Br:18][CH2:19][CH2:20][CH2:21]Br>>[Br:18][CH2:19][CH2:20][CH2:21][O:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:12][S:11][C:10]=2[CH:13]=1

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 223141963-(4-Fluoro-phenyl)-benzo[b]thiophen-6-ol

Product 1

HCID 223140346-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene

Procedure

In analogy to example 27.1, 3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-ol and 1,3-dibromopropane were converted to yield 6-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene, MS: 364 (M, 1Br).

Sources & evidence

ORD record
ord-9dc3b805e81845ae86f819b3ae2fa343
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

Loading…