Bis(2-Methoxyethyl)amine → {3-[3-(4-Bromo-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-bis-(2-methoxy-ethyl)-amine

HRID 270398Notes

Reaction equation

HRID 270398 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20]Br)=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1.[CH3:22][O:23][CH2:24][CH2:25][NH:26][CH2:27][CH2:28][O:29][CH3:30]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][N:26]([CH2:27][CH2:28][O:29][CH3:30])[CH2:25][CH2:24][O:23][CH3:22])=[CH:13][C:10]=3[S:11][CH:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2383Bis(2-Methoxyethyl)amineHCID 223139683-(4-Bromo-phenyl)-6-(3-bromo-propoxy)-benzo[b]thiophene

Product 1

HCID 22314045{3-[3-(4-Bromo-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-bis-(2-methoxy-ethyl)-amine

Procedure

In analogy to example 3.1, 3-(4-Bromo-phenyl)-6-(3-bromo-propoxy)-benzo[b]thiophene and bis(2-methoxyethyl)amine were converted to yield {3-[3-(4-Bromo-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-bis-(2-methoxy-ethyl)-amine as light brown oil, MS: 478 (MH+, 1Br).

Sources & evidence

ORD record
ord-30c98524bf0f419985fabd89d589a58e
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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