2-(Methylamino)ethanol → 2-({3-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-methyl-amino)-ethanol

HRID 270402Notes

Reaction equation

HRID 270402 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[CH:12][S:11][C:10]=2[CH:21]=1.[CH3:22][NH:23][CH2:24][CH2:25][OH:26]>>[F:20][C:17]1[CH:18]=[CH:19][C:14]([C:13]2[C:9]3[CH:8]=[CH:7][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:23]([CH3:22])[CH2:24][CH2:25][OH:26])=[CH:21][C:10]=3[S:11][CH:12]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 223140346-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene

Product 1

HCID 223141182-({3-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-methyl-amino)-ethanol

Procedure

In analogy to example 3.1, 6-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene and 2-(methylamino)ethanol were converted to yield 2-({3-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-methyl-amino)-ethanol as colorless oil, MS: 360 (MH+).

Sources & evidence

ORD record
ord-d8afa53f6422499a917e61c1e8e2bbe2
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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