2-(Ethylamino)ethanol → 2-(Ethyl-{3-[3-(4-fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-amino)-ethanol

HRID 270404Notes

Reaction equation

HRID 270404 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[CH:12][S:11][C:10]=2[CH:21]=1.[CH2:22]([NH:24][CH2:25][CH2:26][OH:27])[CH3:23]>>[CH2:22]([N:24]([CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[CH:12][S:11][C:10]=2[CH:21]=1)[CH2:25][CH2:26][OH:27])[CH3:23]

Participants

3

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 223140346-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene

Product 1

HCID 223140942-(Ethyl-{3-[3-(4-fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-amino)-ethanol

Procedure

In analogy to example 3.1, 6-(3-Bromo-propoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene and 2-(ethylamino)ethanol were converted to yield 2-(Ethyl-{3-[3-(4-fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-propyl}-amino)-ethanol as colorless oil, MS: 374 (MH+).

Sources & evidence

ORD record
ord-0528bfd8b9c04e1bbf84fd37147b185e
Source dataset
uspto-grants-2008_11
Patent number
US07449483B2

Reaction notes

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