HCID 57938746, Verbindung → N-[(1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentyl]-3-(methoxymethyl)tetrahydro-2H-pyran-4-amine

HRID 270545Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 270545
[CH3:1][O:2][CH2:3][CH:4]1[C:9](=O)[CH2:8][CH2:7][O:6][CH2:5]1.[CH:11]([C@:14]1([C:20]([N:22]2[CH2:27][CH2:26][N:25]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=3)[CH2:24][CH2:23]2)=[O:21])[CH2:18][CH2:17][C@@H:16]([NH2:19])[CH2:15]1)([CH3:13])[CH3:12]>>[CH:11]([C@:14]1([C:20]([N:22]2[CH2:27][CH2:26][N:25]([C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:36])([F:37])[F:35])[CH:29]=3)[CH2:24][CH2:23]2)=[O:21])[CH2:18][CH2:17][C@@H:16]([NH:19][CH:9]2[CH2:8][CH2:7][O:6][CH2:5][CH:4]2[CH2:3][O:2][CH3:1])[CH2:15]1)([CH3:13])[CH3:12]

Komponenten

3

Edukt 2

HCID 57938746HCID 57938746, VerbindungHCID 59833571tetrahydro-3-(methoxymethyl)-4H-Pyran-4-one

Produkt 1

HCID 11713224N-[(1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentyl]-3-(methoxymethyl)tetrahydro-2H-pyran-4-amine

Versuchsvorschrift

The title compound was prepared by reductive amination of 3-(methoxymethyl)tetrahydro-4H-pyran-4-one with (1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentanamine using the procedure described for Example 5. MS calculated for C27H40F3N3O3: (M+H) 512; found 512.2.

Quellen und Nachweise

ORD-Eintrag
ord-f7d547762e5b4efbbe9d14fb453e5a51
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07449467B2

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