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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 270545Generated: October 25, 2026

HCID 57938746, compound → N-[(1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentyl]-3-(methoxymethyl)tetrahydro-2H-pyran-4-amine

https://huagongshe.com/reaction/270545

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 57938746HCID 57938746—
Reactanttetrahydro-3-(methoxymethyl)-4H-Pyran-4-oneHCID 59833571—
ProductN-[(1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentyl]-3-(methoxymethyl)tetrahydro-2H-pyran-4-amineHCID 11713224—

Reaction Steps

The title compound was prepared by reductive amination of 3-(methoxymethyl)tetrahydro-4H-pyran-4-one with (1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentanamine using the procedure described for Example 5. MS calculated for C27H40F3N3O3: (M+H) 512; found 512.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07449467B2
Source datasetuspto-grants-2008_11
ORD IDord-f7d547762e5b4efbbe9d14fb453e5a51
Source noteuspto-grants-2008_11