HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(5-(Trifluoromethyl)pyridin-3-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl4-[5-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxylate | HCID 59833555 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(5-(Trifluoromethyl)pyridin-3-yl)piperazine | HCID 59833568 | — |
Reaction Steps
tert-Butyl 4-[5-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxylate (0.24 g, 0.25 mmol) was treated with a 4.0 M solution of HCl in 1,4-dioxane (7 mL) at room temperature for 1 h and concentrated. The residue was used for next step without further purification. MS calculated for C10H12F3N3: (M+H) 232; found 232.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449467B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-a215b14be4bd400b873c3e4a61c764b2 |
| Source note | uspto-grants-2008_11 |