Hydrochloric Acid → 1-(5-(Trifluoromethyl)pyridin-3-yl)piperazine

HRID 270551Notes

Reaction equation

HRID 270551 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:6]=[N:7][CH:8]=1.Cl>O1CCOCC1>[F:22][C:2]([F:1])([F:23])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[N:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59833555tert-Butyl4-[5-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxylate

Product 1

HCID 598335681-(5-(Trifluoromethyl)pyridin-3-yl)piperazine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-[5-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxylate (0.24 g, 0.25 mmol) was treated with a 4.0 M solution of HCl in 1,4-dioxane (7 mL) at room temperature for 1 h and concentrated. The residue was used for next step without further purification. MS calculated for C10H12F3N3: (M+H) 232; found 232.1.

Workup

  1. concentrationconcentrated
  2. customThe residue was used for next step without further purification

Sources & evidence

ORD record
ord-a215b14be4bd400b873c3e4a61c764b2
Source dataset
uspto-grants-2008_11
Patent number
US07449467B2

Reaction notes

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