Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

HRID 270562Notes

Reaction equation

HRID 270562 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22707864HCID 22707864, compound

Product 1

HCID 227078634-[2-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-[2-(trifluoromethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (200 mg, 0.61 mmol) in methylene chloride (5 mL) was added trifluoroacetic acid (2.5 mL). After being stirred at room temperature for 45 min, the solution was concentrated to give an oil. MS calculated for C12H12F3N: (M+H) 228; found 228.1.

Workup

  1. concentrationthe solution was concentrated
  2. customto give an oil

Sources & evidence

ORD record
ord-d773bf59884a4a80927c089699d480b4
Source dataset
uspto-grants-2008_11
Patent number
US07449467B2

Reaction notes

Loading…